منابع مشابه
Drug-Diagnostics Co-Development in Oncology
Developments in genomics are providing a biological basis for the heterogeneity of clinical course and response to treatment that have long been apparent to clinicians. The ability to molecularly characterize human diseases presents new opportunities to develop more effective treatments and new challenges for the design and analysis of clinical trials. In oncology, treatment of broad population...
متن کاملDrug and Pharmacodiagnostic Co-development Statistical Considerations
Developments in genomics and biotechnology provide unprecedented opportunities for the development of effective therapeutics and companion diagnostics for matching the right drug to the right patient. Effective co-development entails many new challenges however, including development of an appropriate diagnostic, its analytical validation, clinical validation and utilization in pivotal trials t...
متن کاملCo-amorphous drug-amino acid formulations
Poorly water soluble drugs are considered a major challenge within development of drug formulations for oral delivery. Several formulations strategies exist to overcome this issue including salt formation and solid dispersions to name a few. Recently, a new formulation approach was introduced combining two drug molecules or a drug and an amino acid to form a so-called co-amorphous system. Sever...
متن کاملDrug-Diagnostics Co-Development in Oncology
The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen-receptor modulator tamoxifen was developed in the 1970s for the treatment of breast cancer, data on estrogen-receptor status were correlated with the treatment outcome. Based on a phase II study performed in patients with advanced breast cancer, published in 1976, the investigators concluded:“a high ...
متن کاملThe Prevalence of Drug-Drug Interaction and Inappropriate Drug Prescription Among the Elderly in Kashan
Background: Drug-drug Interaction (DDI) among the elderly is one of the major healthcare challenges worldwide. The present study assessed the rates of DDI and inappropriate drug prescription among the elderly in Kashan City, Iran. Methods: This descriptive-analytical study was designed, conducted, and reported according to the guideline of Strengthening the Reporting of Observational Studies ...
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ژورنال
عنوان ژورنال: DARU Journal of Pharmaceutical Sciences
سال: 2012
ISSN: 2008-2231
DOI: 10.1186/2008-2231-20-45